CBDA, THCV, CBG, oh my! The cascade of acronyms that fall out of cannabis consumers’ mouths is ever increasing. Often, companies today cite high levels of THC and CBD in their products. Known for high levels of psychoactivity and a plethora of health benefits, respectively, these compounds frequently overshadow discussion of any other cannabinoids. However, we now know better. The value of cannabis isn’t found in one or two phytocannabinoids, it’s found in a host of compounds produced within the plant. So, today, we’re taking a closer look at answering the questions:
- What is CBG? And,
- Should we consume more of it?
What is CBG, Otherwise Known as Cannabigerol?
CBG is starting to hold a special place in some cannabis-lovers hearts. Why? For starters, it’s one of the major phytocannabinoids found within cannabis plants. If that isn’t enough, the research into this compound has demonstrated it to be non-psychoactive. From a health perspective, this is highly important. Many people who would prefer to consume cannabis over conventional pharmaceuticals also find they don’t enjoy the effects of compounds like THC. So, any cannabinoids that produce some form of pharmacological properties without the psychotropic effects are likely to catch the eye of consumers.
That’s why we’re taking a closer look at this major phytocannabinoid to see what the research has to say. Before we decide if CBG does offer consumers any potential benefits, we should begin by examining how CBG interacts with our systems.
What Does CBG Do?
Roughly one decade ago, researchers proved that CBG acts on the endocannabinoid system (ECS) in a variety of ways. The research, published in the British Journal of Pharmacology, was the first evidence that CBG can:
- Activate α2-adrenoceptors
- Bind to both cannabinoid receptors
- Block CB1 and 5-HT1A receptors
Scientists, at this point, became even more interested in CBG. In 2018, researchers published a paper that examined the actions of CBG at both of the cannabinoid receptors within the human system (CB1 and CB2). The data, which was published in Frontiers in Pharmacology, found that CBG interacts with the CB receptors in interesting ways. For example, they showed that CBG appears to respond to its environment and that how CBG behaves “may vary depending on the context of the receptor.” Such context was identified as the location of the receptor, its current state, and the assay utilized to study it. However, the results for CBG’s actions were far more robust when looking at CB2 receptors than CB1.
Perhaps more important than the actions of CBG are the end-results for the consumer. So, what, if any, benefits does CBG offer to consumers?
What are the Potential Benefits of CBG Consumption?
People have long associated cannabis consumption with feelings of hunger. Now, there is evidence that shows CBG may play a role in those feelings. In 2016, researchers produced a paper in Psychopharmacology which showed CBG may play a role in what they called “hyperphagic activity” during times of satiation. In layman’s terms: eating a lot even when full.
When given to rats in a feeding assay of 120-240mg/kg, CBG was shown to increase the number of meals consumed and more than double their food intake. At higher doses, CBG was shown simply to reduce the latency to feed. As a result, the researchers said that CBG should be considered a powerful appetite stimulant and that it “produced no adverse effects on any parameter in the neuromotor tolerability test battery.”
CBG may go beyond encouraging people to eat, however. Some studies have shown that it may even help with inflammation and oxidative stress. That’s partially due to a 2018 study in the International Journal of Molecular Sciences which had indicated that CBG performs both quite well, in fact. Then in 2019, a study indicated that preclinical studies should move forward with CBG-CBD combinations as a route of investigation for treating neuroinflammation. Together, the studies demonstrated that CBG:
- Restored cell anti-oxidant defense
- Increased the expression of Nrf-2, and
- Reduced oxidative stress and inflammatory markers
As such, they recommended “the use of CBG against neurodegeneration and in those pathological conditions where neuroinflammation and oxidative stress play a main role.” Given these neuroprotective properties, are there any more benefits in the same vein?
According to a paper published in Neurotherapeutics, the answer may be ‘yes.’ The researchers who published the paper wanted to examine if CBG has any neuroprotective effects on people suffering from Huntington’s Disease (HD). The paper noted that CBG may go beyond interacting with the CB receptors and work with other elements within the brain. In some cases, the researchers noted that the beneficial antioxidant effects are two-fold:
- With increased activities of catalase and SOD-1, and
- Higher levels of GSH
In conclusion, the researchers said, “CBG appears to have a promising neuroprotective profile for the treatment of HD.” So, who—if anyone—should consume CBG?
Should We Consume More CBG?
Deciding to consume cannabis is a personal choice that should often be made with the advice of one’s doctor. How much, when, and in what form it should be taken shouldn’t be considered lightly in people with severe medical conditions. Usually, however, the best way to consume cannabinoids is through sublingual application. That is, applying a few drops under the tongue. With a product like Revita Oil’s 1:1 CBG tincture, it’s easy to consume the cannabinoids you’re looking for without needing to ingest the psychotropic compounds you’re not. Made with a blend of organic hemp, grape seed, and peppermint oils, it delivers a refreshing, diet-friendly taste. Ideally, people who would benefit the most from consuming more CBG in their diet would include people who:
- Experience inflammation on a daily basis or due to injury
- Want to increase their appetite without receiving the psychoactive effects of cannabis
- Would like a balanced blend of cannabinoids introduced to their ECS in an easy-to-consume manner
If you came to this article wondering what CBG is and if you should consume it or not, you should leave with a solid understanding of what this compound is and why it is so important. If you have more questions about CBG please contact us at your leisure. If you enjoyed this article or found it valuable, please share it with your friends so they can learn more about CBG and what it may do for them!